Journal of medicinal chemistryHepatitis B virusAntiviral AgentsHumansAnimalsBenzamides
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators.
Minghui Liang, Yutong Dou, Jian Zhang, Zechun Yang, Yuanyuan Liu, Mei Wang, Yiyan Mao, Lindan Guan, Aixin Li, Yuqing Cai, Yan Wang, Peng Xue, Lei Zhang, Zhuanchang Wu, Xinyong Liu
Published: 202510.1021/acs.jmedchem.5c02347
Abstract
Hepatitis B virus (HBV) capsid assembly modulators are a promising class of agents for chronic HBV infection. Thioureidobenzamide compound 17i exhibits potent anti-HBV activity but suffers from poor water solubility, high cytotoxicity, and limited dr…
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