Journal of medicinal chemistryHumansCyclin-Dependent Kinase 2Colorectal NeoplasmsAnimalsCyclin-Dependent Kinase 9
Fluorocyclopropyl-Containing Tacrine Derivatives as Potent and Selective Dual CDK2/CDK9 Inhibitors for the Treatment of Colorectal Cancer.
Limeng Wu, Wenjie Liu, Xinyue Ning, Xinyu Li, Zhiya Wang, Zhenshu Li, Yiming Qi, Jiao Xiao, Xiangbo Xu, Xudong Gao, Xinhua Liu, Yingshi Zhang, Zihua Xu, Wenwu Liu, Yonghong Liu
Published: 202510.1021/acs.jmedchem.5c02328
Abstract
CDK2 and CDK9 play critical roles in cell cycle progression and transcriptional regulation, respectively. And CDK2/9 are highly expressed in colorectal cancer (CRC), which dysregulation contributes significantly to CRC pathogenesis. Through structure…
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