Journal of medicinal chemistryStreptococcus pneumoniaeAnti-Bacterial AgentsBenzimidazolesPenicillin-Binding ProteinsMicrobial Sensitivity Tests
Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
Homero Dominguez-Cisneros, Mohini Mohan Konai, Choon Kim, Neha Rana, Rhona Feltzer, Jeshina Janardhanan, Amr M El-Araby, Van T Nguyen, Jed F Fisher, Mayland Chang, Shahriar Mobashery
Published: 202610.1021/acs.jmedchem.5c02273
Abstract
The allosteric site of penicillin-binding protein 2x (PBP2x), an essential enzyme of cell-wall biosynthesis of Streptococcus pneumoniae, was targeted in virtual screening of >2 M compounds. A benzimidazole-2-methanamine hit emerged, which exhibited a…
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