Journal of medicinal chemistryHumansAnimalsMiceImmunotherapyB7-H1 Antigen
Degrader-Drug Conjugate (DDC) Mediated Immunochemotherapy for Tumor Treatment.
Bichun Chen, Jinyu Bai, Huaihuai Shi, Rui Hao, Jiaxin Liang, Hui Tian, Guiyang Yao, Ximing Shao, Hongchang Li, Ruibing Wang, Wu Su, Lijing Fang
Published: 202510.1021/acs.jmedchem.5c02262
Abstract
Due to the heterogeneity of tumors and the complex regulatory mechanisms governing PD-L1 expression, immunotherapy that employs PD-1/PD-L1 inhibitors has shown limited efficacy and relatively low response rates. In this work, we propose that a Degrad…
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