Journal of medicinal chemistryPeptoidsAnti-Bacterial AgentsHumansTriazolesLipid Bilayers
Mechanism of Action and Membrane Interactions of Antibacterial Quaternized Triazolium Peptoids.
Kathakali De, Cassandra Guerinot, Nicolas Charbonnel, Allison Faure, Jérôme Josse, Christopher Aisenbrey, Sophie Faure, Burkhard Bechinger
Published: 202510.1021/acs.jmedchem.5c02254
Abstract
Using antimicrobial peptides as a template, triazolium-based peptoids were designed with strong and selective antibacterial activities. To probe their mechanism, eight distinct peptoids were investigated using biophysical methods with lipid bilayers…
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