Journal of medicinal chemistryAnimalsHumansDrug DesignMiceT-Lymphocytes
Design, Synthesis, and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-986408.
Denise C Grünenfelder, Upender Velaparthi, Jayakumar S Warrier, Louis Chupak, Chetan Padmakar Darne, Bireshwar Dasgupta, T G Murali Dhar, Min Ding, Robert Gentles, Yazhong Huang, Prasada R Jalagam, Manjunatha Narayana Rao Kamble, Raju Mannoori, Scott Martin, Shana L Posy
Published: 202510.1021/acs.jmedchem.5c02240
Abstract
DGKα and DGKζ are intracellular T cell checkpoints that negatively regulate T cell signaling, activation, and tumor immunity. Inhibition of DGKα/ζ is an attractive mechanism for next-generation immunotherapy, with the potential to broaden the respons…
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