Journal of medicinal chemistryHumansPlasma KallikreinStructure-Activity RelationshipAngioedemasHereditary
Plasma Kallikrein Inhibitors for Multiple Disorders: Current Advances and Perspectives.
Haonan Liu, Yujun Deng, Jiali Liu, Zhiwei Wang, Xue-Qin Hu, Yajun Duan, Yuanli Chen, Zhouling Xie
Published: 202510.1021/acs.jmedchem.5c02234
Abstract
Plasma kallikrein (PKal) is a pivotal serine protease involved in the regulation of the kallikrein-kinin system, the complement system, and several other biological pathways. Inhibition of PKal has become a key therapeutic strategy for hereditary ang…
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