Journal of medicinal chemistryAnimalsOsteoporosisMiceStructure-Activity RelationshipFemale
Synthesis and Biological Evaluation of Heterocycle-Fused Pyxinol Derivatives as Anti-osteoporosis Agents.
De-Jie Zhang, Yan-Xin Yue, Yu-Xin Zhang, Long-Yu Xu, Ruo-Nan Ning, Min Jiang, Wen-Wei Qiu
Published: 202510.1021/acs.jmedchem.5c02212
Abstract
A series of novel heterocycle-fused pyxinol compounds was designed and synthesized through structure-activity relationship (SAR)-guided optimization to develop potent inhibitors of RANKL-induced osteoclastogenesis. Among the synthesized derivatives,…
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