Journal of medicinal chemistryAnimalsHumansAntineoplastic AgentsCarrier ProteinsCell Line
Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer.
Moumita Ghosh Chowdhury, Aditya A Singh, Medha Bhattacharyya, Venkatesh Muthukumar, Saumya Kapoor, Akshay Srivastava, Hemant Kumar, Amit Shard
Published: 202510.1021/acs.jmedchem.5c02169
Abstract
Colorectal cancer (CRC) remains a major global health burden, with current treatments primarily focused on eradicating cancer cells. However, chemotherapy-induced gut dysbiosis exacerbates inflammation and disease progression, necessitating innovativ…
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