Journal of medicinal chemistry5'-NucleotidaseHumansAnimalsAdministrationOral
Discovery of ORIC-533, an Orally Bioavailable CD73 Inhibitor That Maintains Activity in High AMP Environments to Reverse Tumor Immunosuppression.
Jared T Moore, Hiroyuki Kawai, Brian R Blank, Kejia Wu, Chien-Hung Yeh, Liusheng Zhu, Johnny D Pham, Yosup Rew, John Eksterowicz, Sumeet Salaniwal, Dena Sutimantanapi, Robert Warne, Natalie Yuen, Todd C Metzger, Brenda Chan
Published: 202510.1021/acs.jmedchem.5c02153
Abstract
Immunosuppressive adenosine (ADO) is catabolized from adenosine monophosphate (AMP) by CD73 in the tumor microenvironment and corresponds to poor patient prognosis in many cancers. Reducing levels of ADO via inhibition of CD73 may reverse this immuno…
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