Journal of medicinal chemistryAnimalsHumansStructure-Activity RelationshipPyroptosisAdministration
Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties.
Nicolò Filippi, Kathleen Mertens, Joni De Loose, Siham Benramdane, Robin Hermans, Margarida Espadinha, Laura Dirkx, Pim-Bart Feijens, Vanesa Nozal, Emile Verhulst, Sarah Peeters, Tiphanie Gomard, Sam Corthaut, Koen Augustyns, Guy Caljon
Published: 202510.1021/acs.jmedchem.5c02049
Abstract
Dipeptidyl peptidase 9 (DPP9) is a key regulator of pyroptosis in leukocytes. DPP9-targeting inhibitors have been reported to selectively induce pyroptosis in human acute myeloid leukemia (AML) cells and work synergistically with non-nucleoside rever…
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