Journal of medicinal chemistryFerroptosisNanoparticlesApoptosisHumansAnimals
Ferroptosis/Apoptosis Induction by an Iridium Complex Encapsulated in PLGA Nanoparticles Enhances Efficacy and Reduces Toxicity in Breast Cancer.
Shunfang Liu, Wenhao Wu, Linrong Fang, Zhiqi Rao, Jiyong Peng, Xiaodan Wang, Chuqin Yu, Jiu Wang
Published: 202610.1021/acs.jmedchem.5c02025
Abstract
Conventional chemotherapy faces systemic toxicity and suboptimal efficacy, necessitating innovative strategies. Herein, three iridium(III) complexes (PIQ, PPY, and BZQ) were synthesized, and PPY exhibited remarkable cytotoxicity against breast cancer…
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