Journal of medicinal chemistryNuclear Receptor Subfamily 4Group AMember 1ApoptosisHumans
Structure-Based Design and Optimization of Bi-Aryl Amide Derivatives as Nur77 Ligands for Nur77-Bcl-2-Dependent Apoptotic Cancer Therapy.
Taige Zhao, Jun Chen, Wenbin Hong, Yijing Zhong, Hongsheng Li, Xiaodan Li, Yingkun Qiu, Lijuan Wang, Zhen Wu, Xiumin Wang, Xueqin Chen, Meijuan Fang
Published: 202510.1021/acs.jmedchem.5c01934
Abstract
Nur77, a member of the NR4A nuclear receptor family, plays a critical role in tumorigenesis and cancer progression. Ligands activating its nongenomic functions hold therapeutic promise in oncology. Our previous work identified NB1, a 4,4'-bipyridyl c…
Preview only. Read the full abstract at the source