Journal of medicinal chemistryHumansAnimalsRadiopharmaceuticalsMiceMembrane Proteins
Linker-Driven Breakthrough: Design of a Novel Linker for Enhanced Theranostic Performance of FAPI Trimer.
Hua Cheng, Liyan Bai, Xuwei Liu, Xiaoyu Pan, Yanli Wang, Yongle Wang, Fengsheng Zhang, Xiaoping Xu, Peng Li, Changning Wang, Shaoli Song
Published: 202510.1021/acs.jmedchem.5c01873
Abstract
Radiolabeled fibroblast activation protein inhibitors (FAPIs) have emerged as promising diagnostic tracers for a wide range of cancers. The FAP trimer strategy has shown the potential to enhance both imaging and therapeutic efficacy in FAP-targeted a…
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