Journal of medicinal chemistryHumansGlutaminaseDrug DesignAnimalsTOR Serine-Threonine Kinases
Design, Synthesis, and Biological Evaluation of Rapamycin Derivatives as the First Mammalian Target of Rapamycin and GLS1 Dual Inhibitors.
Liushun Wu, Mengting Lyu, Dong-Quan Gu, Yin Li, Ying Li, Hongsu Zhao, Tongsheng Wang, Feng-Qing Xu, Deling Wu, Wuxi Zhou
Published: 202510.1021/acs.jmedchem.5c01841
Abstract
The mammalian target of rapamycin (mTOR) and glutaminase 1 (GLS1) are key enzymes regulating metabolic reprogramming in breast cancer. The first generation of mTOR and GLS1 dual inhibitors was designed and synthesized on the basis of anticancer syner…
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