Journal of medicinal chemistryHumansAnimalsPeroxisome Proliferator-Activated ReceptorsDrug DiscoveryFatty Liver
Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.
Zhiling Liang, Lianru Chen, Zibin Liao, Jianming Mao, Yuxia Liu, Zheng Li
Published: 202510.1021/acs.jmedchem.5c01825
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by multiple metabolic and inflammatory pathways. HSD17B13 is a potential therapeutic target for MASH, and PPAR regulates multiple pathological mechanisms related to M…
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