Journal of medicinal chemistryProtein Serine-Threonine KinasesAnimalsDoublecortin-Like KinasesPyrimidinesMice
Discovery of Benzodiazepinepyrimidine Scaffold Derivatives as Potent Doublecortin-Like Kinase 1 (DCLK1) Inhibitors for the Treatment of Acute Inflammatory Diseases.
Shanchao Wu, Lei Wang, Yingqi Song, Changlu Li, Xiaoyao Lu, Qingwei Bu, Keliang Li, Yuping Chen, Hua Sun, Guang Liang, Gaozhi Chen, Chunquan Sheng
Published: 202510.1021/acs.jmedchem.5c01811
Abstract
Doublecortin-like Kinase 1 (DCLK1) is a microtubule-associated serine/threonine protein. It has emerged as a promising therapeutic target for various cancers. Recently, the role of DCLK1 in inflammation has also been widely confirmed. Inhibition of D…
Preview only. Read the full abstract at the source