Journal of medicinal chemistryHistone DemethylasesStomach NeoplasmsHumansbeta CateninAnimals
Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation.
Xing-Jie Dai, Leipeng Xue, Ying Liu, Shu-Wu Wang, Ying Li, Jia-Yi Yin, Hao-Zhe Long, Hui-Min Liu, Ning Wang, Guo-Liang Lu, Yan Li, Hong-Min Liu, Bo Wang, Yi-Chao Zheng
Published: 202510.1021/acs.jmedchem.5c01798
Abstract
Lysine-specific demethylase 1 (LSD1) is a validated cancer therapeutic target, critically implicated in maintaining cancer stem cells (CSCs) across leukemia and solid tumors. Although numerous potent LSD1 inhibitors have been developed, none have rea…
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