Journal of medicinal chemistry
Discovery and Characterization of Zelnecirnon (RPT193), a Potent and Selective CCR4 Antagonist for Allergic Disorders.
Mikhail Zibinsky, Delia Bradford, Dirk G Brockstedt, Ross Corriden, Jeffrey Jackson, Scott Jacobson, Sherry Jiao, Paul D Kassner, John M Ketcham, Lisa Marshall, Akinori Okano, Omar Robles, Jacob Schwarz, Oezcan Talay, Parcharee Tivitmahaisoon
Published: 202610.1021/acs.jmedchem.5c01678
Abstract
The CCR4 pathway plays an important role in a variety of allergic disorders. This receptor is primarily expressed on CD4+ cells, in particular T helper type 2 (Th2) immune cells, allowing these cells to migrate to the inflamed tissue and exacerbate t…
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