Journal of medicinal chemistryHumansOligonucleotidesRibonucleasesRNASmall Interfering
Exploring Chemically Modified Short Activating RNAs to Increase Stability against Nucleases and Enhance Gene Activation.
Jean-Paul Desaulniers, Matthew L Hammill, Ifrodet Giorgees, Virginia Wing-Nam Chiu, Hannah Pendergraff, Sara Aguti, Jon Voutila, Henrik Hansen, Nagy Habib, Yulia Lomonosova, Troels Koch
Published: 202510.1021/acs.jmedchem.5c01648
Abstract
Short activating RNAs (saRNAs) are short duplex RNAs that activate genes in the nucleus of the cell. This induces gene activation, or RNA activation (RNAa), which upregulates gene expression. This activation is in direct contrast to short interfering…
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