Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation.

While immune checkpoint blockade technologies targeting PD-1/PD-L1 have revolutionized cancer therapy, conventional small-molecule inhibitors are still limited by their occupancy-driven mechanisms and require sustained high-dose exposure, which exace…

Preview only. Read the full abstract at the source