Journal of medicinal chemistryHumansProteasome Endopeptidase ComplexImmunotherapyNeoplasmsAnimals
From Breakdown to Breakthrough: Immunoproteasomes Could Revolutionize Immunotherapies.
Cody A Loy, Darci J Trader
Published: 202510.1021/acs.jmedchem.5c01628
Abstract
The immunoproteasome (iCP), a specialized isoform of the constitutive proteasome that is often expressed or upregulated in diseased cells, has quickly become an attractive drug target. With the iCP playing a major role in the generation of MHC-I comp…
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