Journal of medicinal chemistry
A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.
Samsher Singh, Pearly Shuyi Ng, Umayal Lakshmanan, Vikneswaran Mathiyazakan, Thomas Wiggins, Bei Shi Lee, Shi Hua Ang, Sandra Wei Lin Sim, May Delos Santos, Garrett Moraski, Marvin Miller, Michael Berney, Gerhard Grüber, Kevin Pethe
Published: 202610.1021/acs.jmedchem.5c01616
Abstract
The Mycobacterium tuberculosis cytochrome bcc:aa3 (cyt-bcc:aa3) oxidase is a validated drug target for tuberculosis treatment. In addition to telacebec (Q203), a clinical-stage drug candidate, several preclinical cyt-bcc:aa3 inhibitors have been repo…
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