Journal of medicinal chemistryCD4 AntigensHumansHIV-1ImmunoconjugatesHIV Envelope Protein gp120
Antibody-Drug Conjugates Using CD4 Mimics and a Neutralizing Antibody as HIV-1 Entry Inhibitors.
Yutaro Miura, Kohei Tsuji, Takuya Kobayakawa, Kaho Matsumoto, Takeo Kuwata, Riku Matsuzaki, Shuzo Matsushita, Hirokazu Tamamura
Published: 202510.1021/acs.jmedchem.5c01552
Abstract
The development of new anti-HIV drugs with a novel mechanism of action is still required. A human cell surface protein, CD4, is a primary receptor for HIV-1 entry, and we have developed small-molecule CD4-competitive HIV-1 entry inhibitors, including…
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