Journal of medicinal chemistryHumansExtracellular MatrixLung NeoplasmsDrug RepositioningSystems Biology
Systems Biology-Based Drug Repositioning Identifies Extracellular Matrix Module as a Therapeutic Target in Lung Squamous Cell Carcinoma.
Bin Yang, Yuna Shao, Ziyun Zhou, Shuo Wang, Zeyi Liu, Guang Hu
Published: 202510.1021/acs.jmedchem.5c01495
Abstract
Systematic proteomic comparisons across cancer subtypes provide insights into tumor heterogeneity and accelerate discovery of therapeutic targets and drug repositioning. Here, we present a novel computational framework, signature-network-perturbation…
Preview only. Read the full abstract at the source