Journal of medicinal chemistryHumansStructure-Activity RelationshipAntineoplastic AgentsPleckstrin Homology DomainsCell Line
Discovery, Optimization, and Anticancer Activity of Lipid-Competitive Pleckstrin Homology Domain-Containing Family A Inhibitors.
Nathan P Frederick, Xiaofu Cao, Yizhen Jin, Andrew T Lombardo, Jeremy M Baskin
Published: 202510.1021/acs.jmedchem.5c01338
Abstract
Phosphoinositide signaling is a major cellular mechanism controlling cancer cell viability, proliferation, and survival. Yet, inhibition of lipid kinases that produce oncogenic phosphoinositides has afforded only a limited number of efficacious drugs…
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