Journal of medicinal chemistryBasic Helix-Loop-Helix ProteinsHumansErythropoietinAnimalsProlyl-Hydroxylase Inhibitors
Structure-Based Optimization of HIF-2α Agonists That Synergistically Enhance Erythropoietin Production with PHD Inhibitors.
Mengqi Guo, Weiwei Xu, Zhifang Bai, Keming Chen, Fengyao Li, Zecheng Jin, Xiaoyu Chen, Qinghong Shang, Meina Zhang, Xiaotong Diao, Dongming Xu, Hu Zhang, Kaijie Mu, Yuanxun Wang, Taiwei Ly
Published: 202510.1021/acs.jmedchem.5c01257
Abstract
Hypoxia-inducible factor 2α (HIF-2α) is a crucial transcription factor regulating various physiological processes, including angiogenesis and erythropoiesis. The activity of HIF-2α is mainly controlled through oxygen-dependent protein hydroxylation,…
Preview only. Read the full abstract at the source