Journal of medicinal chemistryG(M3) GangliosideHumansAntineoplastic AgentsAnimalsMice
Multivalency Effects: Example of Synthetic Ganglioside GM3 Analogues in the Study of Antitumor Agents.
Fang Liu, Yan Liu, Haipeng Liu, Jiaxu Zhang, Jianhua Xu, Matthieu Sollogoub, Yongmin Zhang
Published: 202610.1021/acs.jmedchem.5c01242
Abstract
Ganglioside GM3 (NeuAcα3Galβ4Glcβ1Cer) is the simplest sialic acid-containing glycosphingolipid and can inhibit tumor growth via multiple pathways. Based on the multivalent effect, we screened mannose-containing GM3 analogues from previously synthesi…
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