Journal of medicinal chemistryLymphomaLarge B-CellDiffuseProto-Oncogene Proteins c-bcl-6Humans
Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma.
Xiaoli Yu, Xueyan Liao, Jingyu Zhang, Hanlin Wang, Xian Li, Jialiang Lu, Huan Zhou, Mingfei Wu, Yuheng Jin, Xin Zhu, Lei Xu, Shenxin Zeng, Youlu Pan, Jia Li, Jinxin Che
Published: 202510.1021/acs.jmedchem.5c01237
Abstract
B-cell lymphoma 6 (BCL6) is a key transcriptional repressor implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). However, current BCL6-targeting agents demonstrate restricted efficacy in vitro and in vivo, and the underlying mecha…
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