Journal of medicinal chemistryColorectal NeoplasmsDiscoidin Domain Receptor 1HumansAnimalsRadiopharmaceuticals
Synthesis and Preclinical Evaluation of DDR1-Targeted Radiotracers for Colorectal Cancer Diagnosis.
Yuze Ma, Jingyue Gao, Kunyao Wang, Wenqi Zhao, Feng Gao
Published: 202510.1021/acs.jmedchem.5c01224
Abstract
Colorectal cancer (CRC) is one of the most common tumors, and discoidin domain receptor 1 (DDR1) expression is significantly higher in CRC. In this study, we designed and synthesized eight novel 68Ga-labeled DDR1-targeted radiotracers. The radiochemi…
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