Journal of medicinal chemistryHumansTriple Negative Breast NeoplasmsAnimalsPyrimidinesAntineoplastic Agents
Discovery of 2-(4-Ureido-piperidin-1-yl)-4-morpholinothieno [3,2-D] Pyrimidines as Orally Bioavailable Phosphoinositide-3-Kinase Inhibitors with In Vitro and In Vivo Antitumor Efficacy in Triple-Negative Breast Cancer.
Shabber Mohammed, Shabu Thakur, Diksha Manhas, Chilakala Nagarjuna Reddy, Abhisheik Eedara, Santosh K Guru, Ajeet Singh, Mahir Bhardwaj, Vaishnavi Kambhampati, Ramajayan Pandian, Boobalan Gopu, Shashi Bhushan, Ram A Vishwakarma, Sai Balaji Andugulapati, Shashank K Singh
Published: 202510.1021/acs.jmedchem.5c01164
Abstract
The phosphoinositide-3-kinase-α is a key regulator of tumor progression across different cancers, including triple-negative breast cancer. Herein, we explored thienopyrimidine and pyridofuropyrimidine cores to identify a PI3K-α inhibitor for the trea…
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