Journal of medicinal chemistryHumansDrug DiscoveryAnimalsProtein DomainsTranscription Factors
Targeting Non-BET Bromodomains: Emerging Opportunities in Drug Discovery.
Huili Li, Fei Jiang, Quan Sun, Jiandong Huang, Xianggui Chen, Dandan He, Xiangchun Shen
Published: 202510.1021/acs.jmedchem.5c01162
Abstract
Bromodomains, epigenetic "readers" of acetylated lysine marks, represent promising therapeutic targets. The clinical limitations of BET inhibitors, together with growing insights into the distinct functions of non-BET members (e.g., ATAD2, CBP/p300,…
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