Journal of medicinal chemistryHumansAnimalsDrug DesignDNA-Directed DNA PolymeraseCell Line
Rational Design and Biological Evaluation of a Novel Polθ Polymerase Inhibitor for Synergistic Targeting of HR-Deficient Cancers.
Ziheng Yu, Zhen Li, Lei Jiang, Yibin Zhang, Jingxue Zhang, Lu Liu, Ying Qu, Yuchen Wei, Mengying Li, Tao Lu, Zhengtao Li, Yadong Chen, Jie Feng
Published: 202510.1021/acs.jmedchem.5c00818
Abstract
DNA polymerase theta (Polθ) is a key enzyme in the theta-mediated end-joining (TMEJ) and a promising target for synthetic lethality-based cancer therapy, particularly in homologous recombination (HR)-deficient tumors. Herein, we designed and optimize…
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