Journal of medicinal chemistryAcinetobacter baumanniiAnti-Bacterial AgentsMicrobial Sensitivity TestsAnimalsRuthenium
Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii.
Kajal Chaudhary, Bhumika Agrahari, Himanshu Sonker, Sayari Dewan, Ritika Gautam Singh
Published: 202510.1021/acs.jmedchem.5c00790
Abstract
No new class of antibiotics active against Acinetobacter baumannii─a critical WHO priority pathogen (2024)─has reached clinical use in over 50 years. To address this, we designed, synthesized, and characterized a novel library of ruthenium arene comp…
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