Journal of chemical information and modelingTumor Suppressor Protein p53DNAProtein MultimerizationMolecular Dynamics SimulationHumans
Toward In Situ Dynamics of DNA-Bound Full-Length p53 Tetramer.
Özlem Demir, Emilia P Barros, Rommie E Amaro
Published: 202610.1021/acs.jcim.5c02509
Abstract
p53 is the most important tumor suppressor in humans as well as the most frequently mutated gene found in human cancers, with ∼50% of all human tumors bearing p53 missense mutations that leave p53 inactive. Restoring p53 activity has been shown to le…
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