Journal of chemical information and modeling
Evidence for Epibatidine Binding to the Desensitization Gate in α7 nAChR from Molecular Dynamics Simulations and Cryo-EM.
Jesko Kaiser, Christoph G W Gertzen, Daniel Mann, Carsten Sachse, Holger Gohlke
Published: 202610.1021/acs.jcim.5c02384
Abstract
The homopentameric α7-nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel widely expressed in the human nervous system and susceptible to allosteric modulation. A recent cryo-EM structure (EMD 22983; PDB ID 7KOX) revealed unassigne…
Preview only. Read the full abstract at the source