Journal of chemical information and modelingTumor Suppressor Protein p53Allosteric RegulationMolecular Dynamics SimulationSmall Molecule LibrariesHumans
Mechanistic Insights into the Allosteric Regulation of P53 Y220C by Small-Molecule Stabilizers.
Yiming Wen, Buying Niu, Jingyi Meng, Danye Chen, Xutong Li, Suilin Zhang, Hans Ågren, Mingyue Zheng, Dan Teng
Published: 202510.1021/acs.jcim.5c02062
Abstract
The p53 Y220C mutation is a recurrent hotspot alteration that induces local unfolding and long-range functional disruption, compromising its tumor suppressor activity. While small-molecule stabilizers targeting this mutation have shown therapeutic pr…
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