Journal of chemical information and modelingProtein Interaction MappingProteinsComputational BiologyModelsMolecular
MicroEnvPPI: Microenvironment-Aware Optimization Enables Generalizable Protein-Protein Interaction Prediction.
Kun Yang, Yifan Chen, Yanshi Wei, Mingrong Xiang, Linlin Zhuo, Xiangzheng Fu, Dongsheng Cao, Wenqian Zhang
Published: 202510.1021/acs.jcim.5c01907
Abstract
Protein-protein interactions (PPIs) play a fundamental role in shaping cellular functional networks and guiding therapeutic target discovery. Although models such as AlphaFold have achieved impressive results in protein structure prediction and PPI i…
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