Journal of chemical information and modelingLigandsReceptorsG-Protein-CoupledMutationHumans
BOLD-GPCRs: A Transformer-Powered App for Predicting Ligand Bioactivity and Mutational Effects across Class A GPCRs.
Davide Provasi, Kirill Konovalov, Nicholas Riina, Olivia Cullen, Marta Filizola
Published: 202610.1021/acs.jcim.5c01858
Abstract
G Protein-Coupled Receptors (GPCRs) are important targets for drug discovery owing to their ability to respond to a broad range of stimuli and their involvement in numerous pathologies. Although traditional ligand-based and structure-based approaches…
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