Journal of chemical information and modelingChemical and Drug Induced Liver InjuryToxicogeneticsHumansAlgorithmsTime Factors
TCN-RDP: Predicting Drug-Induced Liver Injury from Time-Series Toxicogenomic Data.
Zhongyan Zhao, Bin Li, Haochen Zuo, Ruibing Chen, Rui Deng, Jie Geng, Changming Sun, Leyi Wei, Mingxiao Lang, Ran Su
Published: 202510.1021/acs.jcim.5c01678
Abstract
Drug-induced liver injury (DILI) is a major obstacle in drug development, often leading to high failure rates in clinical trials. Traditional toxicological assessments are slow and resource-intensive, making early prediction of hepatotoxicity a signi…
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