Journal of chemical information and modelingMolecular Dynamics SimulationBasic Helix-Loop-Helix ProteinsThermodynamicsLigandsAryl Hydrocarbon Receptor Nuclear Translocator
Structural, Thermodynamic, and Dynamic Descriptors for the Differential Mechanism of HIF-2 Activity Modulators.
Rajat Punia, Gaurav Goel
Published: 202510.1021/acs.jcim.5c01556
Abstract
Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors that are critical for cellular adaptation to low oxygen conditions. Both enhancement and inhibition of HIF-2 activity have been shown to have a significant therapeutic relevance…
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