Journal of agricultural and food chemistryMolecular Docking SimulationMetabolomicsEicosapentaenoic Acidalpha-ChlorohydrinHumans
Eicosapentaenoic Acid Modulates 3-Chloro-1,2-propanediol Dipalmitate Ester-Induced Disrupted Metabolism: A Dual-Approach Analysis Using Nontargeted Metabolomics and Computational Modeling.
Sunan Gao, Yimei Tian, Zhoujing Zhu, Shixin Zhang, Xuzhi Wan, Wei Jia, Haoyu Li, Jingjing Jiao, Zhen Meng, Yu Zhang
Published: 202510.1021/acs.jafc.5c11074
Abstract
3-Chloropropane-1,2-diol (3-MCPD) and its esters (3-MCPDE) are common food contaminants with toxic effects. Our study examined how 3-MCPDE exposure affects metabolism and the potential protective roles of eicosapentaenoic acid (EPA) using urine metab…
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