Journal of agricultural and food chemistryAnimalsGastrointestinal MicrobiomeMiceTryptophanDepression
A Walnut-Derived Peptide WSPSGR Alleviates Depressive-Like Behaviors in Mice via IDO1 Inhibition and Gut Microbiota-Tryptophan Axis Modulation.
Xiao Xiao, Aijin Ma, Zhou Chen, Siting Li, Junxia Xia, Shenghua Ding, Yingmin Jia
Published: 202510.1021/acs.jafc.5c09940
Abstract
Depression is a complex psychiatric disorder with increasing global impact. This study explored the antidepressant mechanisms of Trp-Ser-Pro-Ser-Gly-Arg (WSPSGR), a walnut-derived peptide with indoleamine 2,3-dioxygenase 1 (IDO1) inhibitory activity.…
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