Journal of agricultural and food chemistryRifampinCholesterolAnimalsGenisteinLiver
Genistein Ameliorates Rifampicin-Undermined Hepatic Cholesterol Efflux via the CH25H-LXRα-ABCA Pathway.
Wei Jiang, Ding Zhang, Jinsheng Shen, Xionghong Hu, Xueli Jin, Shelly Tan, Li Zeng, Hankun Wang, Shanshan Han, Jin Chao, Qiuping Peng, Zhaoyang Liu, Qing-Ao Xiao, Lin Han, Yiling Huang
Published: 202610.1021/acs.jafc.5c08641
Abstract
Rifampicin (RFP) is a well-known first-line antitubercular drug recommended by the World Health Organization. However, RFP-induced hepatotoxicity makes it impractical for use in long-term antitubercular therapy, and its mechanism is still incompletel…
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