Journal of agricultural and food chemistryHumansBiflavonoidsLiver NeoplasmsCatechinGlucose
Discovery of a Novel Target Inhibitor Theaflavin against UDP-Glucose Pyrophosphorylase 2 and Its Role in Attenuating the Malignant Phenotype of Liver Cancer Cells via Perturbation of Glucose Metabolism.
Yuxin Zhou, Nan Song, Haonan Hu, Yanli Wang, Ziquan Zhao, Chang Sun, Siying Xie, Ailing Yu, Fanxing Xu, Dahong Li, Miao Chang, Hao Cao
Published: 202510.1021/acs.jafc.5c07617
Abstract
UDP-glucose pyrophosphorylase 2 (UGP2), the unique mammalian enzyme converting glucose-1-phosphate to UDP-glucose, is upregulated in hepatocellular carcinoma (HCC) and other malignancies. It promotes tumor progression through glycogen metabolism and…
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