Inorganic chemistryRosmarinic AcidDepsidesCopperCinnamatesHumans
Rosmarinic Acid Is an hCtr1 Inhibitor that Interferes with Copper Transport Activity.
Fei Chen, Sisi Wu, Jian Kuang, Sijia Xiang, Shenghu Wang, Siming Yuan, Kaiming Cao, Lu Yu, Wenming Yang, Liqin Tang, Yangzhong Liu
Published: 202610.1021/acs.inorgchem.5c04906
Abstract
Human copper transporter 1 (hCtr1) is a transport protein essential for cellular copper uptake and homeostasis, yet excess copper influx is toxic to cells. Currently, no inhibitors of hCtr1 are available to modulate intracellular copper levels. Here,…
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