Environmental science & technologyUric AcidAnimalsHumansCase-Control StudiesKidney
Kidney Urate Underexcretion Mediates the Relationship between Per- and Polyfluoroalkyl Substances and their Alternatives and Uric Acid Levels: Evidence from a Case-Control Study and an Animal Study.
Li-Xia Liang, Wan-Ting He, Yun-Ting Zhang, Mohammed Zeeshan, Zhengmin Qian, Mario Schootman, Stephen Edward McMillin, Shu-Li Xu, Yue Wen, Wen-Wen Bao, Li-Zi Lin, Zhao-Huan Gui, Kun Ye, Guang-Hui Dong
Published: 202610.1021/acs.est.5c11261
Abstract
Numerous studies have indicated a relationship between per- and polyfluoroalkyl substances (PFASs) with uric acid levels; yet, the underlying mechanism remains unclear. To investigate this, we conducted a case-control study with 990 adults and animal…
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