Integration of Transfer Learning and Multitask Learning To Predict the Potential of Per/Polyfluoroalkyl Substances in Activating Multiple Nuclear Receptors Associated with Hepatic Lipotoxicity.

Per/polyfluoroalkyl substances (PFAS) can induce hepatic lipotoxicity by activating nuclear receptors (NRs). Here, we first developed machine-learning models to predict activities of PFAS toward five NRs related to hepatic lipotoxicity using five con…

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