Environmental science & technologyAnimalsZebrafishLarvaPhenylenediaminesGlioma
In-Depth Investigation into the Neurotoxic and Neuroglioma Risks of 6PPD Exposure in Zebrafish Larvae: Benchmark Dose Analysis, Molecular Mechanisms, and Adult Pathological Effects.
Ze-Jun Wang, Xincong Su, Cuizhen Wang, Xiaowen Han, Rongzhi Wang, Xiao Yang, Xuedong Wang, Jin Yan, Qiuhui Qian, Ming Gao, Huili Wang
Published: 202610.1021/acs.est.5c06619
Abstract
As an antioxidant widely used in tire rubber, (1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) has been recognized as an emerging contaminant with unclear neurotoxic potential. Using zebrafish (Danio rerio) as a model, we systematically evalua…
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