Chemical reviewsSpliceosomesRNA SplicingHumansRNA Splicing FactorsMolecular Dynamics Simulation
Decoding Spliceosome Dynamics through Computation and Experiment.
Pavlína Pokorná, Jana Aupič, Sebastian M Fica, Alessandra Magistrato
Published: 202510.1021/acs.chemrev.5c00374
Abstract
RNA splicing is orchestrated by a complex and exceptionally dynamic RNA-protein machine, called the spliceosome. Stepwise, large-scale structural and compositional remodeling of the spliceosome enables splicing and ensures its fidelity. While cryogen…
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